Laboratory of Molecular and Ecological Chemistry

Structure-activity relationship and chemical biology for bioactive compounds from natural and organic synthesis


  • NameE-mail Address
  • Position
  • Degree
  • HASHIMOTO Makoto
  • Professor
  • Ph. D. Pharm.


Researchers’ directory
  • SAKIHAMA Yasuko
  • Professor
  • Doctor (Science)


Researchers’ directory
  • MURAI Yuta
  • Associate Professor
  • Ph. D. Agr.


Researchers’ directory



Professor Hashimoto:

Selected Publications

  1. Makoto Hashimoto*,  Tomoya Nakagita, Takumi Misaka, Recent progress in the use of diaziridine-based sweetener derivatives to elucidate the chemoreception mechanism of the sweet taste receptor, RSC Advances, 11, 32236-32247 (2021);
  2. Makoto Hashimoto*, 00111.Diaziridines and diazirines, In Three-membered Heterocycles, and all Fused Systems with a Three-membered Heterocyclic Ring, Comprehensive Heterocyclic Chemistry IV (Reference Module in Chemistry, Molecular Sciences and Chemical Engineering 2019, 1-16 (2019);
  3. Yasuko Sakihama, Makiko Maeda, Makoto Hashimoto, Satoshi Tahara and Yasuyuki Hashidoko. Beetroot betalain inhibits peroxynitrite-mediated tyrosine nitration and DNA strand cleavage. Free Radical Research 46, 93-99 (2012)
  4. Lei Wang, Akiko Ishida, Yasuyuki Hashidoko, Makoto Hashimoto*, Dehydrogenation of NH-NH Bond Triggered by Potassium t-Butoxide in Liquid NH3, Angew. Chem. Int. Ed., 56, 870-873 (2017), German Ed: Angew. Chem., 129, 888 – 891(2017); DOI: 10.1002/anie.201610371
  5. Zetryana Puteri Tachrim, Lei Wang, Yuta Murai, Takuma Yoshida, Natsumi Kurokawa, Fumina Ohashi, Yasuyuki Hashidoko, Makoto Hashimoto*, Triflouromethanesulfonic Acid as Acylation Catalyst: Special Feature for C- and/or O-Acylation Reactions, Catalysts, 7(2), 40 (2017); doi:10.3390/catal7020040

Specialized Fields

Research Keywords

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